MUCOPOLYSACCHARIDOSIS

[mps2mom]

Mucopolysaccharidoses is a group of inherited diseases in which a defective or missing enzyme causes large amounts of complex sugar molecules to accumulate in harmful amounts in the body's cells and tissues. This accumulation causes permanent, progressive cellular damage that affects appearance, physical abilities, organ and system functioning, and, in most cases, mental development.


MPS Type, Name and Enzyme Deficiency

MPS I
Hurler’s syndrome, a-L-Iduronidase

MPS I S
Scheie, a-L-Iduronidase

MPS I H-S
Hurler-Scheie, a-L-Iduronidase

MPS II
Hunter, Iduronate sulfatase- X linked

MPS III A
Sanfilippo A, Heparan N-sulfatase

MPS III B
Sanfilippo B, α -N-Acetylglucosaminidase (alpha-hexosaminidase)

MPS III C
Sanfilippo C, α -Glucosaminide-N-acetyltransferase

MPS III D
Sanfilippo D, N-Acetylglucosamine 6-sulfatase

MPS IV A
Morquio A, Galactose 6-sulfatase

MPS IV B
Morquio B, B-Galactosidase

MPS VI
Maroteaux-Lamy, (arylsulfatase B) N-Acetylgalactosamine 4-sulfatase

MPS VII
Sly, B-Glucuronidase

MPS IX
Hyaluronidase




For More information about MPS disorders visit www.mpssociety.org